LYMPHOID NEOPLASIA Brief report Mutation of the receptor tyrosine phosphatase PTPRC (CD45) in T-cell acute lymphoblastic leukemia
نویسندگان
چکیده
1Center for the Biology of Disease, VIB, Leuven, Belgium; 2Center for Human Genetics, KU Leuven, Leuven, Belgium; 3Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy; 4Division of Hematology, Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Rome, Italy; 5Inserm U944 and Hematology Laboratory, Hôpital Saint-Louis, Institut Universitaire d’Hématologie, Université Paris Diderot, Paris, France; 6Laboratory Department of Hematology, AZ St Jan Brugge-Oostende AV, Brugge, Belgium; 7Pediatric Hemato-oncology, University Hospitals Leuven, Leuven, Belgium; and 8Centre National de la Recherche Scientifique Unité Mixte de Recherche 8147 and Department of Haematology, Hôpital Necker-Enfants-Malades Assistance Publique–Hôpitaux de Paris, Université Paris-5 Descartes Paris, France
منابع مشابه
Mutation of the receptor tyrosine phosphatase PTPRC (CD45) in T-cell acute lymphoblastic leukemia.
The protein tyrosine phosphatase CD45, encoded by the PTPRC gene, is well known as a regulator of B- and T-cell receptor signaling. In addition, CD45 negatively regulates JAK family kinases downstream of cytokine receptors. Here, we report the presence of CD45 inactivating mutations in T-cell acute lymphoblastic leukemia. Loss-of-function mutations of CD45 were detected in combination with acti...
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